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Runes have many varieties (eg. Battle, Life, Bulwark, Precision etc.) and they all have different available stats. Many funds have a special passive trait, though some gain a random one.

Rune Types
Rune Stats available Bonus stat Craftable? Restrictions
Arcane 20% chance to apply a random debuff on basic attacks No Arcane heroes only
Assassin 20% To apply off balance on basic attacks No Assassins only
Battle  Random Yes None
Bulwark Random Yes None
Caster ?% Chance to purge a buff on hit (basic and special attacks). No None
Corruption [Random]% chance to disease on hit Yes None
Enabler 25% Chance for Epic attack (stacks) No
Hero No None
Demon Deals additional 10% damage for every debuff on the target enemy No Demons only
Dodge Evading No
Life Hp, ? Random Yes None
Ogre 20% chance to lower enemy ATK on a basic attack No Ogres only
Planning Gain bonus XP in PVE Yes None
Plant 20% chance to reflect damage back at melee attackers No Plants only
Precision Crit, ? Random Yes None
Reptile 15% chance to stone on a basic attack No Reptiles only
Unbreakable Heart Once per dungeon, survives first death blow, and health drops to 1 instead (effect stacks) No None
Warrior 20% chance for an extra basic attack (chances stack) No None

Arcane Rune

Bonus Stat / Passive 20% chance to apply a random debuff on basic attacks
Element Dark
Stats Normal, like craftable
Is Craftable No
Source Event
Restriction Arcane Heroes only

Champion Rune

Bonus Stat / Passive Various (Damage Reduction in PvP, Damage Penetration in PvP, Healing, etc) Champion Rune Superior Light (Healer)
Element All Elements
Stats Often a combination of ATK and DEF (depending on the Element)
Is Craftable No
Source PvP Reward
Restriction None

Demonic Rune

Bonus Stat / Passive Deals additional 10% damage for every debuff on the target enemy on basic attacks
Element Water, Fire
Stats ATK, ATK, CRIT (Fire) / DEF. DEF. HEALTH (Water)
Is Craftable No
Source Demon Event
Restriction Demons only

Shield-Piercing Rune

Bonus Stat / Passive basic attacks have Arcane Bolts Icon Shield-piercing effect
Element Water???
Stats Normal, like craftable
Is Craftable No
Source Events
Restriction None

Healer Rune

Bonus Stat / Passive Similar to the Heal Ally Icon Field Dressing trait: Heals 10% of Max Heal at the end of the turn. Healer Rune Superior
Element Water, Light, Fire
Stats A combination of ATK and DEF (depending on the Element)
Is Craftable No
Source Honor Shop, PvP League "Legend" Reward, Events
Restriction None

Enabler Rune

Bonus Stat / Passive 25% chance to make an Epic attack. The chance (%) stacks, is added up. Enabler Rune Elite Light
Element Water, Fire, Nature, Dark, Light
Stats Normal, like craftable
Is Craftable No
Source Events (like Build Your Own Rune Event)
Restriction None

Unbreakable Heart Rune

Bonus Stat / Passive Unbreakable Heart Icon Unbreakable Heart: Avoids death from a death blow, health will stay at 1 HP.
Element Water
Stats common: DEF & HEALTH; very, very rare: ATK as primary and secondary stats (double ATK)
Is Craftable No
Source (Calendar) Events, PvP Rewards, Honor Shop, In-App Shop (bundled with Epics)
Restriction None

Vamiric Rune

Bonus Stat / Passive Heals [10]% of damage dealt. Vampiric Rune Greater Fire
Element Fire, Light, Dark
Stats Normal, like craftable
Is Craftable Yes
Source Events, PvP Rewards, Honor Shop
Restriction None
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